"I came away with two beliefs that have driven my research ever since. First, do the do-able; working on an important but intractable problem would not suit me. Second, engraved in me from Jim Watson: since it is no harder to work on a problem that is important than on one that is not important, always choose the former." --Bob Horvitz
"A good problem should be hard to solve, located in an unpopular area and interesting enough to push you out of bed every morning." --Andrew Murray
"I have no special talent. I am only passionately curious." --Albert Einstein
"For every well-defined physiological problem there is an organism optimally suited to yield an answer." --August Krogh